孙锦
副教授，山东省泰山学者青年专家。
主要研究方向：一是以果蝇肠道为模型，综合利用遗传学、生物信息学、分子生物学、细胞生物学和生物化学的手段，研究肠道干细胞命运决定，以及组织稳态的调控机制；二是以小鼠为模型，研究遗传性耳聋的发病机制，开发基因治疗方法。作为第一作者或共同通讯作者在Developmental Cell, Nature Communications, PNAS, Cell Reports、EMBO reports等国际一流期刊上发表文章9篇。主持和参与了多项国家自然科学基金、科技部科技支撑计划项目和山东省自然科学基金面上项目。
主持基金:
2023年，山东省自然科学基金面上项目
2021年，山东省泰山学者青年专家
2018年，国家自然科学基金青年科学基金项目
发表论文:
第一作者或通讯作者文章（first author*，corresponding author#）：
[1] Sheng Li*, Jin Sun*, Bo-Wen Zhang*, Lu Yang*, Ying-Cui Wan, Bei-Bei Chen, Nan Xu, Qian-Ru Xu, Juan Fan, Jia-Ni Shang, Rui Li, Chen-Ge Yu, Yan Xi#, Su Chen#. ATG5 attenuates inflammatory signaling in mouse embryonic stem cells to control differentiation. Developmental Cell. 2024 Apr 8;59:1-16.
[2] Jin Sun*, Xia Wang*, Rong-Gang Xu*, Decai Mao*, Da Shen*, Xin Wang*, Yuhao Qiu*, Yuting Han*, Xinyi Lu*, Yutong Li*, Qinyun Che, Li Zheng, Ping Peng, Xuan Kang, Ruibao Zhu, Yu Jia, Yinyin Wang, Lu-Ping Liu, Zhijie Chang, Jun-Yuan Ji, Zhao Wang, Qingfei Liu, Shao Li#, Fang-Lin Sun#, Jian-Quan Ni#. HP1c regulates development and gut homeostasis by suppressing Notch signaling through Su(H). EMBO reports. 2021 Apr 7;22(4):e51298
[3] Decai Mao*, Yu Jia*, Ping Peng*, Da Shen*, Xingjie Ren*, Ruibao Zhu*, Yuhao Qiu*, Yuting Han*, Jinchao Yu, Qinyun Che, Yutong Li, Xinyi Lu, Lu-Ping Liu, Zhao Wang, Qingfei Liu, Jin Sun#, Jian-Quan Ni#. Enhanced Efficiency of flySAM by Optimization of sgRNA Parameters in Drosophila. G3 (Bethesda). 2020 Dec; 10(12): 4483–4488.
[4] Qiao HH*, Wang F*, Xu RG*, Sun J*, Zhu R*, Mao D*, Ren X, Wang X, Jia Y, Peng P, Shen D, Liu LP, Chang Z, Wang G, Li S, Ji JY, Liu Q, Ni JQ. An efficient and multiple target transgenic RNAitechnique with low toxicity in Drosophila. Nature Communications. 2018;9(1):4160.
[5] Jia Y, Xu RG, Ren X, Ewen-Campen B, Rajakumar R, Zirin J, Yang-Zhou D, Zhu R, Wang F, Mao D, Peng P, Qiao HH, Wang X, Liu LP, Xu B, Ji JY, Liu Q, Sun J#, Perrimon N#, Ni JQ#. Next-generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM. PNAS. 2018;115(18):4719-24.
[6] Yang Z*, Sun J*, Hu Y*, Wang F*, Wang X*, Qiao HH*, Xu J*, Mao D*, Ren X, Pan LX, Xu RG, Xu BW, Zhang Y, Li H, Miao W, Hu Y, Chang Z, Wang D, Li H, Chang Z, Liu LP, Liu Q, Ni JQ. Histone H1 defect in escort cells triggers germline tumor in Drosophila ovary. Developmental Biology. 2017;424(1):40-49.
[7] Sun J*, Wei HM*, Xu J*, Chang JF, Yang Z, Ren X, Lv WW, Liu LP, Pan LX, Wang X, Qiao HH, Zhu B, Ji JY, Yan D, Xie T, Sun FL, Ni JQ. Histone H1 mediated epigenetic regulation controls germline stem cell self-renewal by modulating H4K16 acetylation. Nature Communications. 2015;6:8856.
[8] Ren X*, Yang Z*, Xu J*, Sun J*, Mao D*, Hu Y, Yang SJ, Qiao HH, Wang X, Hu Q, Deng P, Liu LP, Ji JY, Li JB, Ni JQ. Enhanced specificity and efficiency of the CRISPR/Cas9 system with optimized sgRNA parameters in Drosophila. Cell Reports. 2014;9(3):1151-62.
[9] Ren X*, Sun J*, Housden BE, Hu Y, Roesel C, Lin S, Liu LP, Yang Z, Mao D, Sun L, Wu Q, Ji JY, Xi J, Mohr SE, Xu J, Perrimon N, Ni JQ. Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. PNAS. 2013;110(47): 19012-7.
